About Enhancer
| Enhancer ID: | E_00370 |
| Species: | Mus musculus |
| Position : | chr12:85482048-85490068   |
| Year: | 2016 |
| Title: | Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26595656 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Mouse Cortical Neurons |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Genetic-variant functional analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Fos |
About TF
| TF name : | Mef2c |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mef2c | CDO in myogenesis | reactome | 29 |
| Mef2c | Circadian Clock | reactome | 49 |
| Mef2c | ErbB1 downstream signaling | pid | 105 |
| Mef2c | ERK/MAPK targets | reactome | 17 |
| Mef2c | Notch | netpath | 76 |
| Mef2c | Oxidative stress response | panther | 23 |
| Mef2c | p38 MAPK pathway | panther | 31 |
| Mef2c | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Mef2c | Regulation of retinoblastoma protein | pid | 67 |
| Mef2c | Signaling events mediated by HDAC Class II | pid | 58 |
| Mef2c | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Mef2c | TGF_beta_Receptor | netpath | 220 |
| Mef2c | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Mef2c | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| Mef2c | MAPK signaling pathway | kegg | 264 |
| Mef2c | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Mef2c | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Mef2c | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Mef2c | Hs_Oxidation_by_Cytochrome_P450_WP43_84102 | wikipathways | 14 |
| Mef2c | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer