About Enhancer
| Enhancer ID: | E_00378 |
| Species: | Homo sapiens |
| Position : | chr8:128230503-128380503   |
| Year: | 2014 |
| Title: | Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 24662484 |
| MONDO: | MONDO:0005132 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | FISH, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, RNA Immunoprecipitation, Biotin-labeled RNA pull-down assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | CTCF; TCF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00801 | chr8:128210000-128260000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00819 | chr8:128210000-128260000 | Breast | breast carcinoma cell | breast carcinoma |
| E_01120 | chr8:128220000-128250000 | Heart | cardiomyocyte | -- |
| E_01121 | chr8:128220000-128250000 | Blood | lymphoblastoid cell | -- |
| E_00379 | chr8:128230503-128380503 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00295 | chr8:128231146-128231713 | Breast | breast carcinoma cell | breast carcinoma |
| E_00296 | chr8:128231146-128231713 | Pancreatic islet | pancreatic beta cell | -- |
| E_00908 | chr8:128311200-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_00232 | chr8:128320000-128322000 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00828 | chr8:128320000-128321000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00793 | chr8:128320500-128321500 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00421 | chr8:128322000-128323000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer