About Enhancer
| Enhancer ID: | E_00403 |
| Species: | Homo sapiens |
| Position : | chr8:129165000-129166500   |
| Year: | 2016 |
| Title: | Identification of focally amplified lineage specific super enhancers in human epithelial cancers |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | non-small cell lung carcinoma |
| PMID: | 26656844 |
| MONDO: | MONDO:0005233 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Human non-small cell lung carcinoma cell |
| CVCL ID: | |
| Cell Type: | non-small cell lung carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer functional validation, Transcription factor binding analysis, Genome editing |
| High Throughput Method: | H3K27ac ChIP-seq, p300 ChIP-seq, DNase-seq, NFE2L2 ChIP-seq, CEBPB ChIP-seq, RNA-seq, Gene set enrichment analysis |
| Low Throughput Method: | Luciferase reporter assay, CRISPR-Cas9 enhancer deletion, Chromosome conformation capture RT-qPCR, siRNA knockdown, Clonogenic growth assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NFE2L2; CEBPB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer