About Enhancer
| Enhancer ID: | E_00404 |
| Species: | Homo sapiens |
| Position : | chr8:129166547-129190290   |
| Year: | 2016 |
| Title: | Identification of focally amplified lineage specific super enhancers in human epithelial cancers |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | non-small cell lung carcinoma |
| PMID: | 26656844 |
| MONDO: | MONDO:0005233 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Human non-small cell lung carcinoma cell |
| CVCL ID: | |
| Cell Type: | non-small cell lung carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Epigenomic mapping, Enhancer functional validation, Genome editing |
| High Throughput Method: | GISTIC copy number analysis, H3K27ac ChIP-seq, p300 ChIP-seq, DNase-seq, RNA-seq, NFE2L2 ChIP-seq, CEBPB ChIP-seq, Gene set enrichment analysis |
| Low Throughput Method: | Luciferase reporter assay, CRISPR-Cas9 enhancer deletion, CRISPR dCas9 KRAB repression, Chromosome conformation capture RT-qPCR, siRNA knockdown, Clonogenic growth assay, Anchorage independent growth assay, TaqMan RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NFE2L2; CEBPB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00255 | chr8:129180000-129190000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00256 | chr8:129180000-129190000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00257 | chr8:129180000-129190000 | Lymph node | B cell | Burkitt lymphoma |
| E_00258 | chr8:129180000-129190000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00259 | chr8:129190000-129195000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00260 | chr8:129190000-129195000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00261 | chr8:129190000-129195000 | Lymph node | B cell | Burkitt lymphoma |
| E_00262 | chr8:129190000-129195000 | Blood | leukemia cell | leukemia |
Expression of Target Genes for the Enhancer