About Enhancer
| Enhancer ID: | E_00418 |
| Species: | Homo sapiens |
| Position : | chr6:135515000-135515800   |
| Year: | 2016 |
| Title: | Recurrent rearrangements of the MYB locus in adenoid cystic carcinoma drive oncogenic expression through enhancer hijacking |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | salivary gland adenoid cystic carcinoma |
| PMID: | 27362228 |
| MONDO: | MONDO:0015066 |
| Tissue: | Salivary gland |
| Tissue Ontology ID: | UBERON:0001044 |
| Cell Source: | ACC patient-derived xenograft cell lines (ACCX2, ACCX9, ACCX12, ACCX19, ACCX22) |
| CVCL ID: | |
| Cell Type: | adenoid cystic carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, 3C, FISH, RT-RT-qPCR |
About Target Gene
| Target gene : | MYB |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer