About Enhancer
| Enhancer ID: | E_00419 |
| Species: | Homo sapiens |
| Position : | chr8:128740000-128790000   |
| Year: | 2015 |
| Title: | Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 25801169 |
| MONDO: | MONDO:0005132 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT-116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | TCF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF4 | AndrogenReceptor | netpath | 167 |
| TCF4 | CDO in myogenesis | reactome | 29 |
| TCF4 | Coregulation of Androgen receptor activity | pid | 61 |
| TCF4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF4 | ID | netpath | 38 |
| TCF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF4 | TGF_beta_Receptor | netpath | 220 |
| TCF4 | Wnt | netpath | 118 |
| TCF4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
20 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00502 | chr8:128744932-128746104 | Prostate gland | prostate carcinoma cell | prostate cancer |
| E_00112 | chr8:128745000-128752600 | Epithelium | breast epithelial cell | Cancer |
| E_00650 | chr8:128745000-128745100 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00175 | chr8:128747000-128750000 | Cervical Epithelium | cervical adenocarcinoma cell | cervical cancer |
| E_00646 | chr8:128747000-128753000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01094 | chr8:128747000-128748000 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00945 | chr8:128747680-128753680 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_00891 | chr8:128748243-128748308 | Brain | neural stem cell | -- |
| E_01102 | chr8:128748315-128750245 | Dermis | dermal lymphatic endothelial cell | -- |
| E_00595 | chr8:128748351-128800823 | Pulmonary artery | pulmonary artery endothelial cell | -- |
| E_00596 | chr8:128748351-128800823 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00636 | chr8:128749000-128750000 | Esophagus | esophageal squamous cell carcinoma cell | esophageal squamous cell carcinoma |
| E_00167 | chr8:128750000-129000000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00651 | chr8:128750000-128750100 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00606 | chr8:128751884-128753219 | Colon | colon epithelial cell | -- |
| E_01293 | chr8:128753000-128754000 | Endometrium | endometrial adenocarcinoma cell | endometrial adenocarcinoma |
| E_01104 | chr8:128754000-128755000 | Breast | breast carcinoma cell | breast carcinoma |
| E_01105 | chr8:128754000-128755000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00881 | chr8:128765000-128767000 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00882 | chr8:128765000-128767000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer