About Enhancer
| Enhancer ID: | E_00422 |
| Species: | Homo sapiens |
| Position : | chr11:63800000-63802500   |
| Year: | 2023 |
| Title: | Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 37832549 |
| MONDO: | |
| Tissue: | Connective Tissue |
| Tissue Ontology ID: | UBERON:0002384 |
| Cell Source: | Human Mesenchymal Progenitor |
| CVCL ID: | |
| Cell Type: | mesenchymal progenitor cell |
| Cell Ontology ID: | CL:0000134 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | Hi-C, ChIP-seq |
| Low Throughput Method: | CRISPRa, RT-RT-qPCR |
About Target Gene
| Target gene : | HMGB2 |
About TF
| TF name : | SOX5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX5 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| SOX5 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00637 | chr11:63800000-63802500 | Endometrium | endometrial adenocarcinoma cell | endometrial adenocarcinoma |
Expression of Target Genes for the Enhancer