About Enhancer
| Enhancer ID: | E_00437 |
| Species: | Homo sapiens |
| Position : | chr10:23508400-23508721   |
| Year: | 2022 |
| Title: | Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 35998583 |
| MONDO: | |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | Pancreatic Multipotent Progenitor Cells (MPCs) |
| CVCL ID: | |
| Cell Type: | pancreatic multipotent progenitor cell |
| Cell Ontology ID: | CL:0002583 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq, scATAC-seq |
| Low Throughput Method: | CRISPR Knockout, qRT-PCR, Immunofluorescence |
About Target Gene
| Target gene : | PTF1A |
About TF
| TF name : | PDX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PDX1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| PDX1 | Regulation of gene expression in beta cells | reactome | 17 |
| PDX1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| PDX1 | Type II diabetes mellitus | kegg | 44 |
| PDX1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00906 | chr10:23508149-23508510 | Pancreas | progenitor cell | -- |
Expression of Target Genes for the Enhancer