About Enhancer
| Enhancer ID: | E_00443 |
| Species: | Mus musculus |
| Position : | chr11:32145028-32146147   |
| Year: | 2016 |
| Title: | Genetic dissection of the ζ±-globin super-enhancer in vivo. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27376235 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary mouse erythroid cells / enhancer-deletion mice |
| Cell Type: | erythroid cell |
| Experiment Type: | Endogenous constituent-enhancer knockout; chromatin and 3D-conformation dissection |
| High Throughput Method: | ChIP-seq; chromatin profiling; Capture-C/3C-based interaction mapping |
| Low Throughput Method: | Targeted enhancer deletion mouse; RT-qPCR; chromatin assays |
About Target Gene
| Target gene : | Hba-a2 |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
44 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00068 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00069 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00070 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00071 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00072 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00073 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00074 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00075 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00084 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00085 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00086 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00087 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00088 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00089 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00090 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00091 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00205 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00206 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00207 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00208 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00209 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00210 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00211 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00212 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00442 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_00444 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_00445 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_02543 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02544 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02545 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02546 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02547 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02548 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02549 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02550 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_03320 | chr11:32145028-32146147 | liver | erythroid cell | NA |
| E_03474 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03475 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03476 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03477 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03478 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03479 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
Expression of Target Genes for the Enhancer