About Enhancer
| Enhancer ID: | E_00446 |
| Species: | Homo sapiens |
| Position : | chr3:128250000-128350000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MUTZ-3 |
| CVCL ID: | CVCL_1435 |
| Cell Type: | myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, 3C-seq |
| Low Throughput Method: | RT-RT-qPCR, FISH |
About Target Gene
| Target gene : | EVI1 |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00445 | chr3:128250000-128350000 | Peripheral Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00680 | chr3:128300000-128301000 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00681 | chr3:128300000-128301000 | Bone Marrow | CD34-positive hematopoietic stem cell | -- |
| E_00436 | chr3:128322357-128323157 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer