About Enhancer
| Enhancer ID: | E_00448 |
| Species: | Homo sapiens |
| Position : | chr7:92350000-92450000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0011998 |
| Tissue: | Peripheral Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | chronic myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, 3C-seq |
| Low Throughput Method: | RT-RT-qPCR, FISH |
About Target Gene
| Target gene : | EVI1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00401 | chr7:92384001-92385000 | Blood | induced pluripotent stem cell | -- |
| E_00402 | chr7:92384001-92385000 | Blood | hematopoietic stem cell | -- |
| E_00684 | chr7:92400000-92401000 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00685 | chr7:92400000-92401000 | Bone Marrow | CD34-positive hematopoietic stem cell | -- |
Expression of Target Genes for the Enhancer