About Enhancer
| Enhancer ID: | E_00450 |
| Species: | Homo sapiens |
| Position : | chr7:128579302-128580416   |
| Year: | 2023 |
| Title: | An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 36869052 |
| MONDO: | |
| Tissue: | Peripheral Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary CD14+ monocytes |
| CVCL ID: | |
| Cell Type: | CD14-positive monocyte |
| Cell Ontology ID: | CL:0001053 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, 3C-seq |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA, ChIP-RT-qPCR, 3C assay, 4C assay, RT-RT-qPCR |
About Target Gene
| Target gene : | IRF5 |
About TF
| TF name : | ZBTB3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer