About Enhancer
| Enhancer ID: | E_00523 |
| Species: | Homo sapiens |
| Position : | chr1:92948000-92952000   |
| Year: | 2022 |
| Title: | GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 34980595 |
| MONDO: | MONDO:0004947 |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Jurkat T-ALL |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | GFI1 |
About TF
| TF name : | GFI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GFI1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer