About Enhancer
| Enhancer ID: | E_00536 |
| Species: | Homo sapiens |
| Position : | chr17:69108466-69108765   |
| Year: | 2012 |
| Title: | Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q243 prostate cancer risk locus |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 22665440 |
| MONDO: | |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF10A |
| CVCL ID: | CVCL_0598 |
| Cell Type: | breast epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, DNase-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, Sanger sequencing |
About Target Gene
| Target gene : | SOX9 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00537 | chr17:69108466-69108765 | Prostate | prostate carcinoma cell | prostate cancer |
Expression of Target Genes for the Enhancer