About Enhancer
| Enhancer ID: | E_00549 |
| Species: | Homo sapiens |
| Position : | chr2:202122500-202124030   |
| Year: | 2016 |
| Title: | Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | mantle cell lymphoma |
| PMID: | 26795348 |
| MONDO: | MONDO:0005052 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Rec-1 |
| CVCL ID: | CVCL_1884 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | CASP8 |
About TF
| TF name : | STAT3; MYC; CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00534 | chr2:202122200-202123730 | Breast | breast epithelial cell | -- |
| E_00550 | chr2:202122500-202124030 | Breast | breast epithelial cell | -- |
| E_00951 | chr2:202122994-202122996 | Breast | breast epithelial cell | -- |
| E_00512 | chr2:202122995-202124526 | Breast | mammary epithelial cell | -- |
| E_00513 | chr2:202122995-202124526 | Breast | breast epithelial cell | -- |
| E_00514 | chr2:202122995-202124526 | Breast | breast carcinoma cell | breast carcinoma |
| E_00515 | chr2:202122995-202124526 | Breast | breast carcinoma cell | breast carcinoma |
| E_00952 | chr2:202123429-202123431 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer