About Enhancer
| Enhancer ID: | E_00591 |
| Species: | Homo sapiens |
| Position : | chr14:56265000-56275000   |
| Year: | 2018 |
| Title: | Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 29348663 |
| MONDO: | MONDO:0005132 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HT29 |
| CVCL ID: | CVCL_0320 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, chromatin interaction assay |
| High Throughput Method: | ChIP-seq, Hi-C, 4C-seq |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR |
About Target Gene
| Target gene : | NOS3 |
About TF
| TF name : | KLF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| KLF4 | Synthesis, secretion, and deacylation of Ghrelin | reactome | 17 |
| KLF4 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| KLF4 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF4 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| KLF4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| KLF4 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer