About Enhancer
| Enhancer ID: | E_00594 |
| Species: | Homo sapiens |
| Position : | chr8:41090000-41090300   |
| Year: | 2023 |
| Title: | SOX17 enhancer variants disrupt transcription factor binding and enhancer inactivity drives pulmonary hypertension |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 37066790 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep3B |
| CVCL ID: | CVCL_0326 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR |
About Target Gene
| Target gene : | SOX17 |
About TF
| TF name : | RORA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RORA | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| RORA | Circadian Clock | reactome | 49 |
| RORA | HIF-1-alpha transcription factor network | pid | 67 |
| RORA | Nuclear Receptor transcription pathway | reactome | 51 |
| RORA | PPARA activates gene expression | reactome | 113 |
| RORA | RORA activates gene expression | reactome | 27 |
| RORA | Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 | wikipathways | 15 |
| RORA | Hs_Complement_and_Coagulation_Cascades_WP558_90196 | wikipathways | 21 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer