About Enhancer
| Enhancer ID: | E_00615 |
| Species: | Homo sapiens |
| Position : | chr9:27520189-27520340   |
| Year: | 2020 |
| Title: | A TGF-??- and p63-Responsive Enhancer Regulates IFN-?? Expression in Human Keratinocytes |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 32060133 |
| MONDO: | |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | Normal human keratinocytes |
| CVCL ID: | |
| Cell Type: | keratinocyte |
| Cell Ontology ID: | CL:0000312 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA, ChIP-RT-qPCR, siRNA knockdown, qRT-PCR, Western blot |
About Target Gene
| Target gene : | IFNK |
About TF
| TF name : | TFAP2A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TFAP2A | Caspase Cascade in Apoptosis | pid | 57 |
| TFAP2A | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
| TFAP2A | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| TFAP2A | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
| TFAP2A | Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer