About Enhancer
| Enhancer ID: | E_00625 |
| Species: | Homo sapiens |
| Position : | chr5:149432000-149433000   |
| Year: | 2015 |
| Title: | CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 26423156 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HepG2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | NKX2.5 |
About TF
| TF name : | SRF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SRF | Coregulation of Androgen receptor activity | pid | 61 |
| SRF | ErbB1 downstream signaling | pid | 105 |
| SRF | Interleukin signaling pathway | panther | 86 |
| SRF | p38 MAPK pathway | panther | 31 |
| SRF | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| SRF | PDGF signaling pathway | panther | 113 |
| SRF | PDGFR-alpha signaling pathway | pid | 22 |
| SRF | PDGFR-beta signaling pathway | pid | 125 |
| SRF | Ras Pathway | panther | 69 |
| SRF | RHO GTPases Activate Formins | reactome | 114 |
| SRF | RhoA signaling pathway | pid | 46 |
| SRF | Signaling events mediated by HDAC Class II | pid | 58 |
| SRF | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| SRF | MAPK signaling pathway | kegg | 264 |
| SRF | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| SRF | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| SRF | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SRF | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00626 | chr5:149432000-149433000 | Heart | cardiac precursor cell | -- |
| E_00627 | chr5:149432000-149433000 | Heart | cardiac precursor cell | -- |
| E_00628 | chr5:149433000-149434000 | Heart | cardiac precursor cell | -- |
| E_00629 | chr5:149433000-149434000 | Heart | cardiac precursor cell | -- |
| E_00641 | chr5:149433000-149434000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer