About Enhancer
| Enhancer ID: | E_00626 |
| Species: | Homo sapiens |
| Position : | chr5:149432000-149433000   |
| Year: | 2015 |
| Title: | CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 26423156 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Cardiac precursor |
| CVCL ID: | |
| Cell Type: | cardiac precursor cell |
| Cell Ontology ID: | CL:0002248 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | GATA4 |
About TF
| TF name : | GATA4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA4 | Notch-mediated HES/HEY network | pid | 48 |
| GATA4 | Physiological factors | reactome | 12 |
| GATA4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| GATA4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| GATA4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| GATA4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| GATA4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00625 | chr5:149432000-149433000 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_00627 | chr5:149432000-149433000 | Heart | cardiac precursor cell | -- |
| E_00628 | chr5:149433000-149434000 | Heart | cardiac precursor cell | -- |
| E_00629 | chr5:149433000-149434000 | Heart | cardiac precursor cell | -- |
| E_00641 | chr5:149433000-149434000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer