About Enhancer
| Enhancer ID: | E_00629 |
| Species: | Homo sapiens |
| Position : | chr5:149433000-149434000   |
| Year: | 2015 |
| Title: | CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 26423156 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Cardiac precursor |
| CVCL ID: | |
| Cell Type: | cardiac precursor cell |
| Cell Ontology ID: | CL:0002248 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | MEF2C |
About TF
| TF name : | MEF2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEF2C | CDO in myogenesis | reactome | 29 |
| MEF2C | Circadian Clock | reactome | 49 |
| MEF2C | ErbB1 downstream signaling | pid | 105 |
| MEF2C | ERK/MAPK targets | reactome | 17 |
| MEF2C | Notch | netpath | 76 |
| MEF2C | Oxidative stress response | panther | 23 |
| MEF2C | p38 MAPK pathway | panther | 31 |
| MEF2C | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| MEF2C | Regulation of retinoblastoma protein | pid | 67 |
| MEF2C | Signaling events mediated by HDAC Class II | pid | 58 |
| MEF2C | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| MEF2C | TGF_beta_Receptor | netpath | 220 |
| MEF2C | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| MEF2C | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| MEF2C | MAPK signaling pathway | kegg | 264 |
| MEF2C | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| MEF2C | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| MEF2C | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| MEF2C | Hs_Oxidation_by_Cytochrome_P450_WP43_84102 | wikipathways | 14 |
| MEF2C | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00625 | chr5:149432000-149433000 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_00626 | chr5:149432000-149433000 | Heart | cardiac precursor cell | -- |
| E_00627 | chr5:149432000-149433000 | Heart | cardiac precursor cell | -- |
| E_00628 | chr5:149433000-149434000 | Heart | cardiac precursor cell | -- |
| E_00641 | chr5:149433000-149434000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_00630 | chr5:149434000-149435000 | Heart | cardiac precursor cell | -- |
| E_00631 | chr5:149434000-149435000 | Heart | cardiac precursor cell | -- |
Expression of Target Genes for the Enhancer