About Enhancer
| Enhancer ID: | E_00633 |
| Species: | Homo sapiens |
| Position : | chr6:170855462-170856787   |
| Year: | 2014 |
| Title: | Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 24413736 |
| MONDO: | |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Human Bronchial Epithelial Cells (HBEC1) |
| CVCL ID: | |
| Cell Type: | bronchial epithelial cell |
| Cell Ontology ID: | CL:0002591 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay |
About Target Gene
| Target gene : | TBP |
About TF
| TF name : | NKX2-2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NKX2-2 | Regulation of gene expression in beta cells | reactome | 17 |
| NKX2-2 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | reactome | 5 |
| NKX2-2 | Maturity onset diabetes of the young | kegg | 25 |
| NKX2-2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer