About Enhancer
| Enhancer ID: | E_00636 |
| Species: | Homo sapiens |
| Position : | chr8:128749000-128750000   |
| Year: | 2014 |
| Title: | FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal squamous cell carcinoma |
| PMID: | 24512546 |
| MONDO: | MONDO:0005082 |
| Tissue: | Esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | KYSE-30 |
| CVCL ID: | CVCL_1351 |
| Cell Type: | esophageal squamous cell carcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | FOXA1; AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00419 | chr8:128740000-128790000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00112 | chr8:128745000-128752600 | Epithelium | breast epithelial cell | Cancer |
| E_00175 | chr8:128747000-128750000 | Cervical Epithelium | cervical adenocarcinoma cell | cervical cancer |
| E_00646 | chr8:128747000-128753000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00945 | chr8:128747680-128753680 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_01102 | chr8:128748315-128750245 | Dermis | dermal lymphatic endothelial cell | -- |
| E_00595 | chr8:128748351-128800823 | Pulmonary artery | pulmonary artery endothelial cell | -- |
| E_00596 | chr8:128748351-128800823 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00167 | chr8:128750000-129000000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00651 | chr8:128750000-128750100 | Colon | colorectal carcinoma cell | colorectal cancer |
Expression of Target Genes for the Enhancer