About Enhancer
| Enhancer ID: | E_00639 |
| Species: | Homo sapiens |
| Position : | chr22:29165000-29175000   |
| Year: | 2026 |
| Title: | KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 41849608 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | AsPC1 |
| CVCL ID: | CVCL_0152 |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Regulatory element functional validation, 3D chromatin interaction mapping |
| High Throughput Method: | ATAC-seq, ChIP-seq, HiChIP, RNA-seq, nascent RNA-seq |
| Low Throughput Method: | dCas9-KRAB epigenetic silencing, RT-RT-qPCR, Western blot, flow cytometry, multiplex immunofluorescence |
About Target Gene
| Target gene : | BCL2L1 |
About TF
| TF name : | KLF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer