About Enhancer
| Enhancer ID: | E_00660 |
| Species: | Homo sapiens |
| Position : | chr2:172949712-172954378   |
| Year: | 2021 |
| Title: | Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 34493733 |
| MONDO: | MONDO:0008315 |
| Tissue: | Prostate |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | VCaP |
| CVCL ID: | CVCL_2235 |
| Cell Type: | prostate carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | DLX1 |
About TF
| TF name : | ERG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ERG | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ERG | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ERG | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ERG | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ERG | PDGF signaling pathway | panther | 113 |
| ERG | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer