About Enhancer
| Enhancer ID: | E_00691 |
| Species: | Homo sapiens |
| Position : | chr14:106328838-106329184   |
| Year: | 2024 |
| Title: | Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 38934080 |
| MONDO: | MONDO:0005042 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Human DLBCL cell |
| CVCL ID: | |
| Cell Type: | diffuse large B-cell lymphoma cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay |
| High Throughput Method: | CRISPRi screening, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPRi, RT-RT-qPCR, Western blot, Flow Cytometry, GFP competition assay |
About Target Gene
| Target gene : | BCL2 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00690 | chr14:106328838-106329184 | Blood | Burkitt lymphoma cell | Burkitt lymphoma |
| E_00692 | chr14:106328838-106329184 | Blood | B-cell lymphoma cell | B-cell lymphoma |
| E_00869 | chr14:106328838-106329184 | Blood | Burkitt lymphoma cell | Burkitt lymphoma |
| E_00870 | chr14:106328838-106329184 | Blood | diffuse large B-cell lymphoma cell | diffuse large B-cell lymphoma |
Expression of Target Genes for the Enhancer