About Enhancer
| Enhancer ID: | E_00693 |
| Species: | Homo sapiens |
| Position : | chr14:57419008-57421445   |
| Year: | 2020 |
| Title: | A distal enhancer that directs Otx2 expression in the retinal pigment epithelium and neuroretina |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | -- |
| PMID: | 31658410 |
| MONDO: | |
| Tissue: | Retina |
| Tissue Ontology ID: | UBERON:0000966 |
| Cell Source: | |
| CVCL ID: | |
| Cell Type: | |
| Cell Ontology ID: | |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, Hi-C, DNase-seq |
| Low Throughput Method: | Transgenic Reporter Assay, qRT-PCR, Immunohistochemistry |
About Target Gene
| Target gene : | OTX2 |
About TF
| TF name : | PAX6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX6 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| PAX6 | CDC42 signaling events | pid | 71 |
| PAX6 | Regulation of gene expression in beta cells | reactome | 17 |
| PAX6 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| PAX6 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| PAX6 | Maturity onset diabetes of the young | kegg | 25 |
| PAX6 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer