About Enhancer
| Enhancer ID: | E_00711 |
| Species: | Homo sapiens |
| Position : | chr12:117827344-117845711   |
| Year: | 2026 |
| Title: | Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPK??1 stabilization |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 41424849 |
| MONDO: | |
| Tissue: | Umbilical vein |
| Tissue Ontology ID: | UBERON:0002066 |
| Cell Source: | HUVECs |
| CVCL ID: | |
| Cell Type: | umbilical vein endothelial cell |
| Cell Ontology ID: | CL:0002615 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, EMSA, siRNA knockdown, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | KSR2 |
About TF
| TF name : | XBP1S |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer