About Enhancer
| Enhancer ID: | E_00726 |
| Species: | Homo sapiens |
| Position : | chr8:48025841-48796048   |
| Year: | 2024 |
| Title: | Nuclear respiratory factor 1 regulates super enhancer-controlled SPIDR to protect hepatocellular carcinoma cells from oxidative stress |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 38438958 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Huh7 |
| CVCL ID: | CVCL_0336 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Western blot, CCK-8 Assay, ROS Assay, ELISA, Immunofluorescence |
About Target Gene
| Target gene : | SPIDR |
About TF
| TF name : | NRF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NRF1 | PPARA activates gene expression | reactome | 113 |
| NRF1 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| NRF1 | Huntington's disease | kegg | 182 |
| NRF1 | Hs_Energy_Metabolism_WP1541_91584 | wikipathways | 13 |
| NRF1 | Hs_Mitochondrial_Gene_Expression_WP391_71373 | wikipathways | 11 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00727 | chr8:48025841-48796048 | Liver | hepatocyte | -- |
Expression of Target Genes for the Enhancer