About Enhancer
| Enhancer ID: | E_00752 |
| Species: | Homo sapiens |
| Position : | chr16:86543000-86544500   |
| Year: | 2015 |
| Title: | GATA2 is required for lymphatic vessel valve development and maintenance |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 26214525 |
| MONDO: | |
| Tissue: | Dermis |
| Tissue Ontology ID: | UBERON:0002067 |
| Cell Source: | Primary Dermal Lymphatic Endothelial Cells (hLECs) |
| CVCL ID: | |
| Cell Type: | dermal lymphatic endothelial cell |
| Cell Ontology ID: | CL:0002546 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay |
About Target Gene
| Target gene : | FOXC2 |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer