About Enhancer
| Enhancer ID: | E_00758 |
| Species: | Homo sapiens |
| Position : | chr12:79345000-79347000   |
| Year: | 2013 |
| Title: | Switch enhancers interpret TGF-beta signaling |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 24332857 |
| MONDO: | |
| Tissue: | Embryonic stem cell tissue |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Human embryonic stem cells (hESC) |
| CVCL ID: | |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, Signal switching assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase reporter assay, siRNA, RT-RT-qPCR |
About Target Gene
| Target gene : | NANOG |
About TF
| TF name : | SMAD2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SMAD2 | Alpha6Beta4Integrin | netpath | 74 |
| SMAD2 | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 |
| SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | reactome | 23 |
| SMAD2 | Downregulation of TGF-beta receptor signaling | reactome | 26 |
| SMAD2 | EGFR1 | netpath | 475 |
| SMAD2 | Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 8 |
| SMAD2 | Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 7 |
| SMAD2 | Glypican 1 network | pid | 26 |
| SMAD2 | Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 21 |
| SMAD2 | Regulation of cytoplasmic and nuclear SMAD2/3 signaling | pid | 20 |
| SMAD2 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| SMAD2 | Signaling by Activin | reactome | 11 |
| SMAD2 | Signaling by NODAL | reactome | 19 |
| SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer | reactome | 7 |
| SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | reactome | 6 |
| SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| SMAD2 | SnoN degradation signaling ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 38 |
| SMAD2 | TGF-beta receptor signaling activates SMADs | reactome | 12 |
| SMAD2 | TGF-beta receptor signaling | pid | 53 |
| SMAD2 | TGF-beta signaling pathway | panther | 88 |
| SMAD2 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| SMAD2 | TGF_beta_Receptor | netpath | 220 |
| SMAD2 | TGFBR1 KD Mutants in Cancer | reactome | 7 |
| SMAD2 | TNFalpha | netpath | 274 |
| SMAD2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| SMAD2 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| SMAD2 | Cell cycle | kegg | 124 |
| SMAD2 | Endocytosis | kegg | 201 |
| SMAD2 | Wnt signaling pathway | kegg | 135 |
| SMAD2 | TGF-beta signaling pathway | kegg | 82 |
| SMAD2 | Adherens junction | kegg | 70 |
| SMAD2 | Chagas disease | kegg | 103 |
| SMAD2 | Pathways in cancer | kegg | 321 |
| SMAD2 | Colorectal cancer | kegg | 63 |
| SMAD2 | Pancreatic cancer | kegg | 70 |
| SMAD2 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| SMAD2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| SMAD2 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
| SMAD2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SMAD2 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer