About Enhancer
| Enhancer ID: | E_00764 |
| Species: | Homo sapiens |
| Position : | chr21:36179867-36180107   |
| Year: | 2020 |
| Title: | Disruption of super-enhancer-driven tumor suppressor gene RCAN14 expression promotes the malignancy of breast carcinoma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 32771023 |
| MONDO: | |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | Human Mammary Epithelial Cells (HMEC) |
| CVCL ID: | |
| Cell Type: | mammary epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, qRT-PCR |
About Target Gene
| Target gene : | RCAN1.4 |
About TF
| TF name : | RUNX3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX3 | TGF_beta_Receptor | netpath | 220 |
| RUNX3 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
| RUNX3 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01149 | chr21:36179867-36180107 | Breast | mammary epithelial cell | -- |
| E_01150 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01151 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01152 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01153 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01154 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer