About Enhancer
| Enhancer ID: | E_00778 |
| Species: | Mus musculus |
| Position : | chr4:115040426-115042426   |
| Year: | 2016 |
| Title: | Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26809507 |
| Cell Source: | HPC-7 |
| CVCL ID: | CVCL_RB19 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq; Hi-C |
| Low Throughput Method: | ChIP-qPCR/ChIP; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Tal1 |
About TF
| TF name : | E2f4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| E2f4 | Cyclin D associated events in G1 | reactome | 38 |
| E2f4 | E2F transcription factor network | pid | 77 |
| E2f4 | G0 and Early G1 | reactome | 25 |
| E2f4 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| E2f4 | Regulation of retinoblastoma protein | pid | 67 |
| E2f4 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| E2f4 | TGF_beta_Receptor | netpath | 220 |
| E2f4 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | reactome | 18 |
| E2f4 | Cell cycle | kegg | 124 |
| E2f4 | TGF-beta signaling pathway | kegg | 82 |
| E2f4 | Hs_GPCRs,_Class_B_Secretin-like_WP334_79716 | wikipathways | 6 |
| E2f4 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| E2f4 | Hs_MAPK_Cascade_WP422_72129 | wikipathways | 10 |
| E2f4 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
15 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00775 | chr4:115040426-115042426 | NA | NA | NA |
| E_00776 | chr4:115040426-115042426 | NA | NA | NA |
| E_00777 | chr4:115040426-115042426 | NA | NA | NA |
| E_00779 | chr4:115040426-115042426 | NA | NA | NA |
| E_00780 | chr4:115040426-115042426 | NA | NA | NA |
| E_00781 | chr4:115040426-115042426 | NA | NA | NA |
| E_00782 | chr4:115040426-115042426 | NA | NA | NA |
| E_00783 | chr4:115040426-115042426 | NA | NA | NA |
| E_00784 | chr4:115040426-115042426 | NA | NA | NA |
| E_00785 | chr4:115040426-115042426 | NA | NA | NA |
| E_00786 | chr4:115040426-115042426 | NA | NA | NA |
| E_00787 | chr4:115040426-115042426 | NA | NA | NA |
| E_00788 | chr4:115040426-115042426 | NA | NA | NA |
| E_00789 | chr4:115040426-115042426 | NA | NA | NA |
| E_00790 | chr4:115040426-115042426 | NA | NA | NA |
Expression of Target Genes for the Enhancer