About Enhancer
| Enhancer ID: | E_00798 |
| Species: | Homo sapiens |
| Position : | chr1:47220000-47260000   |
| Year: | 2023 |
| Title: | Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 38102337 |
| MONDO: | MONDO:0004947 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MOLT-3 |
| CVCL ID: | CVCL_2288 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, shRNA Knockdown, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00797 | chr1:47220000-47260000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer