About Enhancer
| Enhancer ID: | E_00827 |
| Species: | Homo sapiens |
| Position : | chr22:35767741-35768741   |
| Year: | 2013 |
| Title: | The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cervical cancer |
| PMID: | 22370642 |
| MONDO: | MONDO:0001156 |
| Tissue: | Cervix |
| Tissue Ontology ID: | UBERON:0000002 |
| Cell Source: | HeLa cells |
| CVCL ID: | CVCL_0030 |
| Cell Type: | cervical adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | HMOX1 |
About TF
| TF name : | NFE2L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2L2 | Protein processing in endoplasmic reticulum | kegg | 166 |
| NFE2L2 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| NFE2L2 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer