About Enhancer
| Enhancer ID: | E_00829 |
| Species: | Homo sapiens |
| Position : | chr3:128124000-128125500   |
| Year: | 2014 |
| Title: | A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 24703906 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | AML blasts |
| CVCL ID: | |
| Cell Type: | myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | RT-RT-qPCR |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00914 | chr3:128124000-128125500 | Bone Marrow | hematopoietic stem and progenitor cell | -- |
Expression of Target Genes for the Enhancer