About Enhancer
| Enhancer ID: | E_00834 |
| Species: | Homo sapiens |
| Position : | chr10:131265950-131266000   |
| Year: | 2024 |
| Title: | dCas9/CRISPRa-based methylation of O6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 38224404 |
| MONDO: | MONDO:0005142 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | LN18 glioma cells |
| CVCL ID: | CVCL_1352 |
| Cell Type: | glioblastoma cell |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay |
| High Throughput Method: | RNA-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, qRT-PCR, Western blot |
About Target Gene
| Target gene : | MGMT |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer