About Enhancer
| Enhancer ID: | E_00861 |
| Species: | Homo sapiens |
| Position : | chr11:75928700-75928930   |
| Year: | 2019 |
| Title: | Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | small cell lung carcinoma |
| PMID: | 31231131 |
| MONDO: | MONDO:0005020 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | SCLC cell line H889 |
| CVCL ID: | CVCL_1599 |
| Cell Type: | small cell lung carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About TF
| TF name : | ASCL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ASCL1 | Notch-mediated HES/HEY network | pid | 48 |
| ASCL1 | Notch | netpath | 76 |
| ASCL1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| ASCL1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01246 | chr11:75928700-75928930 | Lung | small cell lung carcinoma cell | small cell lung carcinoma |
Expression of Target Genes for the Enhancer