About Enhancer
| Enhancer ID: | E_00906 |
| Species: | Homo sapiens |
| Position : | chr10:23508149-23508510   |
| Year: | 2014 |
| Title: | Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 24212882 |
| MONDO: | |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | hESC-derived progenitors |
| CVCL ID: | |
| Cell Type: | progenitor cell |
| Cell Ontology ID: | CL:0000037 |
| Experiment Type: | TF binding assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | EMSA |
About Target Gene
| Target gene : | PTF1A |
About TF
| TF name : | FOXA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA2 | FOXA1 transcription factor network | pid | 45 |
| FOXA2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| FOXA2 | Regulation of gene expression in beta cells | reactome | 17 |
| FOXA2 | Maturity onset diabetes of the young | kegg | 25 |
| FOXA2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| FOXA2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| FOXA2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| FOXA2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00437 | chr10:23508400-23508721 | Pancreas | pancreatic multipotent progenitor cell | -- |
Expression of Target Genes for the Enhancer