About Enhancer
| Enhancer ID: | E_00908 |
| Species: | Homo sapiens |
| Position : | chr8:128311200-128667652   |
| Year: | 2016 |
| Title: | Active medulloblastoma enhancers reveal subgroup-specific cellular origins |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | medulloblastoma |
| PMID: | 26814967 |
| MONDO: | MONDO:0005146 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | HD-MB03 |
| CVCL ID: | CVCL_IT11 |
| Cell Type: | medulloblastoma cell |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Transgenic reporter assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | HLX |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HLX | IL12-mediated signaling events | pid | 62 |
| HLX | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
33 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00378 | chr8:128230503-128380503 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00379 | chr8:128230503-128380503 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00232 | chr8:128320000-128322000 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00828 | chr8:128320000-128321000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00793 | chr8:128320500-128321500 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00421 | chr8:128322000-128323000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_01090 | chr8:128410475-128411974 | Bronchus | bronchial smooth muscle cell | -- |
| E_00922 | chr8:128423748-128424352 | Breast | breast carcinoma cell | breast carcinoma |
| E_00923 | chr8:128482486-128483650 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_01135 | chr8:128520000-128551676 | Stomach | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
| E_01136 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01137 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01138 | chr8:128520000-128551676 | Prostate | prostate epithelial cell | -- |
| E_00376 | chr8:128526339-128526710 | Kidney | renal cell carcinoma cell | renal cell carcinoma |
| E_00377 | chr8:128526339-128526710 | Kidney | kidney proximal tubule epithelial cell | -- |
| E_00199 | chr8:128531465-128532665 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00200 | chr8:128531465-128532665 | Skin | melanoma cell | skin melanoma |
| E_00201 | chr8:128531465-128532665 | Skin | melanoma cell | skin melanoma |
| E_00202 | chr8:128531465-128532665 | Umbilical vein | umbilical vein endothelial cell | -- |
| E_00214 | chr8:128531465-128532665 | Brain | glioblastoma cell | glioblastoma |
| E_00246 | chr8:128533830-128534830 | Bone Marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01068 | chr8:128540000-128620000 | Salivary gland | adenoid cystic carcinoma cell | salivary gland adenoid cystic carcinoma |
| E_01069 | chr8:128540000-128620000 | Prostate gland | prostate carcinoma cell | prostate cancer |
| E_00831 | chr8:128588859-128589357 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00830 | chr8:128589642-128590670 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00845 | chr8:128647663-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_00846 | chr8:128647663-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_00847 | chr8:128647663-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_00848 | chr8:128647663-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_00380 | chr8:128662857-128663857 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00381 | chr8:128662857-128663857 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00805 | chr8:128667652-128669252 | Brain | medulloblastoma cell | medulloblastoma |
| E_00806 | chr8:128667652-128669252 | Brain | medulloblastoma cell | medulloblastoma |
Expression of Target Genes for the Enhancer