About Enhancer
| Enhancer ID: | E_00912 |
| Species: | Homo sapiens |
| Position : | chr9:133205353-133205796   |
| Year: | 2012 |
| Title: | Expression of ABO blood-group genes is dependent upon an erythroid cell-specific regulatory element |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | gastric adenocarcinoma |
| PMID: | 22408256 |
| MONDO: | MONDO:0005050 |
| Tissue: | Stomach |
| Tissue Ontology ID: | UBERON:0000945 |
| Cell Source: | KATO III cells |
| CVCL ID: | CVCL_1290 |
| Cell Type: | gastric adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase reporter assay, EMSA |
About Target Gene
| Target gene : | ABO |
About TF
| TF name : | NFYA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFYA | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| NFYA | ATF4 activates genes | reactome | 25 |
| NFYA | ATF6-alpha activates chaperone genes | reactome | 10 |
| NFYA | Direct p53 effectors | pid | 141 |
| NFYA | PPARA activates gene expression | reactome | 113 |
| NFYA | TGF_beta_Receptor | netpath | 220 |
| NFYA | Validated targets of C-MYC transcriptional repression | pid | 63 |
| NFYA | Antigen processing and presentation | kegg | 75 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer