About Enhancer
| Enhancer ID: | E_00925 |
| Species: | Homo sapiens |
| Position : | chr13:43111372-43112072   |
| Year: | 2008 |
| Title: | An enhancer upstream of TNFSF11 mediates activation by vitamin D3 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | osteosarcoma |
| PMID: | 18202151 |
| MONDO: | MONDO:0005087 |
| Tissue: | Bone |
| Tissue Ontology ID: | UBERON:0001474 |
| Cell Source: | MG-63 |
| CVCL ID: | CVCL_0426 |
| Cell Type: | osteosarcoma cell |
| Cell Ontology ID: | CL:0000062 |
| Experiment Type: | TF binding assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | EMSA, ChIP-RT-qPCR |
About Target Gene
| Target gene : | TNFSF11 |
About TF
| TF name : | VDR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| VDR | Direct p53 effectors | pid | 141 |
| VDR | Nuclear Receptor transcription pathway | reactome | 51 |
| VDR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| VDR | Retinoic acid receptors-mediated signaling | pid | 30 |
| VDR | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| VDR | TGF_beta_Receptor | netpath | 220 |
| VDR | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| VDR | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| VDR | Vitamin D metabolism and pathway | panther | 6 |
| VDR | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer