About Enhancer
| Enhancer ID: | E_00954 |
| Species: | Homo sapiens |
| Position : | chr11:5225000-5227000   |
| Year: | 2016 |
| Title: | Utility of next-generation RNA-sequencing in identifying chimeric transcription involving human endogenous retroviruses |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 26818267 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | T-47D |
| CVCL ID: | CVCL_0553 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | TF binding assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | EMSA |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00972 | chr11:5224750-5226210 | Bladder | bladder carcinoma cell | bladder carcinoma |
| E_00974 | chr11:5224750-5226210 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00320 | chr11:5225000-5225500 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00822 | chr11:5225000-5227000 | Bone Marrow | CD34-positive hematopoietic stem cell | -- |
| E_00973 | chr11:5225400-5225774 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_01279 | chr11:5226889-5226999 | Bone marrow | CD34-positive hematopoietic stem cell | -- |
Expression of Target Genes for the Enhancer