About Enhancer
| Enhancer ID: | E_00959 |
| Species: | Mus musculus |
| Position : | chr2:11621753-11635500   |
| Year: | 2023 |
| Title: | Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 37922339 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002370 |
| Cell Source: | DN thymocytes |
| Cell Type: | double negative thymocyte |
| Cell Ontology ID: | CL:0002489 |
| Experiment Type: | Regulatory element functional validation, 3D chromatin interaction mapping; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | ChIP-seq, HiChIP, RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 deletion, flow cytometry, reporter assay; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Il2ra |
About TF
| TF name : | Rbpj |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Rbpj | Alzheimer disease-presenilin pathway | panther | 98 |
| Rbpj | Angiogenesis | panther | 141 |
| Rbpj | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| Rbpj | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| Rbpj | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| Rbpj | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| Rbpj | NICD traffics to nucleus | reactome | 13 |
| Rbpj | Notch-HLH transcription pathway | reactome | 13 |
| Rbpj | Notch-mediated HES/HEY network | pid | 48 |
| Rbpj | Notch | netpath | 76 |
| Rbpj | Notch signaling pathway | panther | 27 |
| Rbpj | Notch signaling pathway | pid | 58 |
| Rbpj | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Rbpj | NOTCH2 intracellular domain regulates transcription | reactome | 12 |
| Rbpj | Pre-NOTCH Transcription and Translation | reactome | 29 |
| Rbpj | Presenilin action in Notch and Wnt signaling | pid | 46 |
| Rbpj | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| Rbpj | Notch signaling pathway | kegg | 44 |
| Rbpj | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00960 | chr2:11621753-11635500 | thymus | double negative thymocyte | NA |
Expression of Target Genes for the Enhancer