About Enhancer
| Enhancer ID: | E_00972 |
| Species: | Homo sapiens |
| Position : | chr11:5224750-5226210   |
| Year: | 2007 |
| Title: | Beta-globin intergenic transcription and histone acetylation dependent on an enhancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | bladder carcinoma |
| PMID: | 17283048 |
| MONDO: | MONDO:0005094 |
| Tissue: | Bladder |
| Tissue Ontology ID: | UBERON:0001255 |
| Cell Source: | T24 |
| CVCL ID: | CVCL_0554 |
| Cell Type: | bladder carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, RNase protection assay, RNA FISH, DNA FISH |
About Target Gene
| Target gene : | HBE1 |
About TF
| TF name : | NFE2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00974 | chr11:5224750-5226210 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00320 | chr11:5225000-5225500 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00822 | chr11:5225000-5227000 | Bone Marrow | CD34-positive hematopoietic stem cell | -- |
| E_00954 | chr11:5225000-5227000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00973 | chr11:5225400-5225774 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
Expression of Target Genes for the Enhancer