About Enhancer
| Enhancer ID: | E_00973 |
| Species: | Homo sapiens |
| Position : | chr11:5225400-5225774   |
| Year: | 2004 |
| Title: | An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic myeloid leukemia |
| PMID: | 15371553 |
| MONDO: | MONDO:0011998 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | K562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | chronic myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, RNase protection assay, DNase I hypersensitivity assay, Restriction enzyme accessibility assay |
About Target Gene
| Target gene : | HBE1 |
About TF
| TF name : | NFE2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00972 | chr11:5224750-5226210 | Bladder | bladder carcinoma cell | bladder carcinoma |
| E_00974 | chr11:5224750-5226210 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00320 | chr11:5225000-5225500 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00822 | chr11:5225000-5227000 | Bone Marrow | CD34-positive hematopoietic stem cell | -- |
| E_00954 | chr11:5225000-5227000 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer