About Enhancer
| Enhancer ID: | E_00985 |
| Species: | Mus musculus |
| Position : | chr1:190181400-190182400   |
| Year: | 2023 |
| Title: | A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36697821 |
| Tissue: | lymphatic vessel |
| Tissue Ontology ID: | UBERON:0001473 |
| Cell Source: | orthogonal TF occupancy in primary human dermal lymphatic endothelial cells |
| Cell Type: | lymphatic endothelial cell |
| Cell Ontology ID: | CL:0002138 |
| Experiment Type: | Enhancer activity assay; TF-binding assay; chromatin-interaction assay; endogenous functional perturbation; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | ChIP-seq; RNA-seq; transcriptome profiling |
| Low Throughput Method: | CRISPR-Cas9 GATA2-site deletion; transgenic lacZ reporter; ChIP-qPCR/ChIP; 3C; immunofluorescence; flow cytometry; CRISPR-Cas9 endogenous deletion/editing; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Prox1 |
About TF
| TF name : | Nfatc1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nfatc1 | AP-1 transcription factor network | pid | 71 |
| Nfatc1 | BCR signaling pathway | pid | 70 |
| Nfatc1 | Ca2+ pathway | reactome | 62 |
| Nfatc1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Nfatc1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| Nfatc1 | CLEC7A (Dectin-1) induces NFAT activation | reactome | 13 |
| Nfatc1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| Nfatc1 | FCERI mediated Ca+2 mobilization | reactome | 41 |
| Nfatc1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Nfatc1 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| Nfatc1 | RANKL | netpath | 84 |
| Nfatc1 | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 |
| Nfatc1 | Signaling by Wnt | reactome | 10 |
| Nfatc1 | TCR | netpath | 261 |
| Nfatc1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| Nfatc1 | Wnt signaling pathway | panther | 250 |
| Nfatc1 | Wnt signaling pathway | kegg | 135 |
| Nfatc1 | Axon guidance | kegg | 126 |
| Nfatc1 | VEGF signaling pathway | kegg | 70 |
| Nfatc1 | Natural killer cell mediated cytotoxicity | kegg | 125 |
| Nfatc1 | T cell receptor signaling pathway | kegg | 105 |
| Nfatc1 | B cell receptor signaling pathway | kegg | 70 |
| Nfatc1 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Nfatc1 | Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 | wikipathways | 8 |
| Nfatc1 | Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 | wikipathways | 60 |
| Nfatc1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
36 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00910 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00911 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00912 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00913 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00980 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00981 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00982 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00983 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00984 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00986 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00987 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00988 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00989 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00990 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00991 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00992 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00993 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00994 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00995 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00996 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00997 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00998 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00999 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01000 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01001 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01002 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01003 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01004 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01005 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01006 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01007 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01008 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01021 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01022 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01023 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00969 | chr1:190181703-190182534 | lymphatic vessel | lymphatic endothelial cell | NA |
Expression of Target Genes for the Enhancer