About Enhancer
| Enhancer ID: | E_00995 |
| Species: | Homo sapiens |
| Position : | chr12:12874700-12875275   |
| Year: | 2021 |
| Title: | Lupus susceptibility region containing CDKN1B rs34330 mechanistically influences expression and function of multiple target genes, also linked to proliferation and apoptosis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal adenocarcinoma |
| PMID: | 33982894 |
| MONDO: | MONDO:0005132 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Caco-2 |
| CVCL ID: | CVCL_0025 |
| Cell Type: | colorectal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | ChIP-RT-qPCR |
About Target Gene
| Target gene : | CDKN1B |
About TF
| TF name : | IRF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| IRF1 | Glucocorticoid receptor regulatory network | pid | 85 |
| IRF1 | IFN-gamma pathway | pid | 43 |
| IRF1 | IL12 signaling mediated by STAT4 | pid | 33 |
| IRF1 | IL6-mediated signaling events | pid | 48 |
| IRF1 | Interferon alpha/beta signaling | reactome | 67 |
| IRF1 | Interferon gamma signaling | reactome | 88 |
| IRF1 | Regulation of Telomerase | pid | 70 |
| IRF1 | TRAF6 mediated IRF7 activation | reactome | 33 |
| IRF1 | Hepatitis C | kegg | 134 |
| IRF1 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
Expression of Target Genes for the Enhancer