About Enhancer
| Enhancer ID: | E_01005 |
| Species: | Mus musculus |
| Position : | chr1:190181400-190182400   |
| Year: | 2023 |
| Title: | A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36697821 |
| Tissue: | lymphatic vessel |
| Tissue Ontology ID: | UBERON:0001473 |
| Cell Source: | primary human dermal lymphatic endothelial cells for orthogonal occupancy validation |
| Cell Type: | lymphatic endothelial cell |
| Cell Ontology ID: | CL:0002138 |
| Experiment Type: | Prox1 ?11-kb enhancer; direct TF occupancy; enhancer-promoter interaction; endogenous GATA2-motif editing; in vivo lineage phenotyping |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 5-bp GATA2-site editing; transgenic lacZ reporter; ChIP-qPCR; 3C; immunofluorescence; flow cytometry; OP9 differentiation; mouse genetic phenotyping |
About Target Gene
| Target gene : | Prox1 |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
36 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00910 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00911 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00912 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00913 | chr1:190181400-190182400 | lymphatic vessel | endothelial cell of lymphatic vessel | NA |
| E_00980 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00981 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00982 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00983 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00984 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00985 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00986 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00987 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00988 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00989 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00990 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00991 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00992 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00993 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00994 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00995 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00996 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00997 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00998 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00999 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01000 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01001 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01002 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01003 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01004 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01006 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01007 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01008 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01021 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01022 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_01023 | chr1:190181400-190182400 | lymphatic vessel | lymphatic endothelial cell | NA |
| E_00969 | chr1:190181703-190182534 | lymphatic vessel | lymphatic endothelial cell | NA |
Expression of Target Genes for the Enhancer