About Enhancer
| Enhancer ID: | E_01048 |
| Species: | Mus musculus |
| Position : | chr2:74075311-74075843   |
| Year: | 2022 |
| Title: | Context-dependent enhancer function revealed by targeted inter-TAD relocation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 35715427 |
| Tissue: | limb |
| Tissue Ontology ID: | UBERON:0002101 |
| Cell Source: | E12.5 distal forelimb cells |
| Cell Type: | limb bud mesenchymal cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin accessibility assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | ATAC-seq; CUT&RUN; Capture Hi-C |
| Low Throughput Method: | Transgenic LacZ reporter assay; pronuclear injection; HOX13-binding-site mutagenesis; CRISPR-Cas9 deletion; targeted enhancer relocation; whole-mount in situ hybridization; RT-qPCR |
About Target Gene
| Target gene : | Hoxd12 |
About TF
| TF name : | Hoxa13 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01047 | chr2:74075311-74075843 | limb | limb bud mesenchymal cell | NA |
| E_01049 | chr2:74075311-74075843 | limb | limb bud mesenchymal cell | NA |
| E_01050 | chr2:74075311-74075843 | limb | limb bud mesenchymal cell | NA |
| E_01051 | chr2:74075311-74075843 | limb | limb bud mesenchymal cell | NA |
| E_01052 | chr2:74075311-74075843 | limb | limb bud mesenchymal cell | NA |
Expression of Target Genes for the Enhancer